biological activity and efficient synthesis of 3, 4-dihydropyrimidin-2-(1h)-one/thione derivatives

the present study aimed to use a method for the synthesis of some 3, 4-dihydropyrimidin-2-(1h) - ones/thiones. the study tried to answer the question whether this reaction can be performed without solvent and with new catalyst or not. to find answer to the question, we described a novel protocol for the efficient synthesis of 3, 4-dihydropyrimidin-2-(1h)-one derivatives using aromatic aldehyde, ethylacetoacetate, and urea/thiourea under solvent-free conditions by using sio 2 -cacl 2 as a catalyst. using this catalyst has some advantages; it's high yields, usable in mild conditions, available, reusable, ecofriendly, cost effective and environmentally friendly. the structural features of the synthesized compounds were characterized by ir, 1 h nmr and 13 c nmr. the compounds were screened for antimicrobial activity. the results showed these compounds react against all the tested bacteria. we have demonstrated a novel method for the synthesis of substituted dihydropyrimidinones catalyzed by sio 2 -cacl 2 under solvent-free conditions.